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| 桂西地区骨质疏松患者FRAX评分与体质量指数及外周血中钙、磷指标的相关性分析 |
| Correlation analysis between FRAX score and body mass index and calcium and phosphorus indexes in peripheral blood of patients with osteoporosis in western Guangxi |
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| DOI：10.3969/j.issn.1006-7108.2021.01.026 |
| 中文关键词: FRAX评分 骨质疏松 骨密度 钙磷指标 内分泌 |
| 英文关键词:FRAX osteoporosis bone mineral density calcium and phosphorus index endocrine |
| 基金项目:国际课题《IOF对骨量减少人群骨折风险评估（FRAX）前瞻性研究》（IOFCJO-D001）；2018年广西科技处计划项目（2018JJA140238） |
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| 中文摘要: |
| 目的 探讨桂西地区骨质疏松患者FRAX评分与体质量指数及外周血中钙、磷指标的相关性。方法 随机选取右江民族医学院附属医院2015年1～6月住院患者221例，根据纳入标准筛选出69例。诊断为骨质疏松患者33例，男12例，女21例；诊断为非骨质疏松患者36例，男18例，女18例。随访并计算FRAX评分、收集相关临床电解质指标后采用独立样本t检验分别统计分析骨质疏松组和非疏松组整体人群相关患者钙、磷离子值。多重线性回归分析未来10年骨折风险概率/体质量指数（PMOF/BMI）、10年内髋部骨折概率/体质量指数（PHF/BMI）之间的关系。研究桂西地区患者FRAX评分及BMI与外周血中钙、磷指标是否存在相应关系。结果 在骨质疏松组患者和整体人群中，外周血钙、磷及年龄等因素与PMOF和PHF之间均没有相关性（各项P值均＞0.05）。在骨质疏松组中，BMI与PMOF和PHF之间没有相关性（P值均＞0.05）。但是在整体人群中，BMI与PMOF和PHF之间有线性相关性（P＜0.05），并且随着BMI增加，PMOF和PHF的数值越来越小。结论 骨质疏松患者外周血钙、磷指标与骨质疏松骨折风险无明显相关性。依据本试验统计学分析，钙、磷指标在本算法中不能作为桂西地区诊断骨质疏松骨折风险的依据；在整体人群中，BMI与PMOF和PHF之间呈现负向相关性，提示低BMI人群容易发生骨折。 |
| 英文摘要: |
| Objective To investigate the correlation between FRAX score and body mass index and calcium and phosphorus indexes in peripheral blood of patients with osteoporosis in western Guangxi. Methods From January 2015 to June 2015, 221 patients were randomly selected from the Affiliated Hospital of Youjiang Medical College for nationalities, and 69 cases were screened according to the inclusion criteria. Thirty-three patients were diagnosed as osteoporosis, including 12 males and 21 females. Thirty-six patients were diagnosed as non-osteoporosis, including 18 males and 18 females. After follow-up, FRAX score was calculated. The relevant clinical electrolyte indicators were collected. The independent sample t test was used to statistically analyze the calcium and phosphorus ion values of the whole population of patients in the osteoporosis group and the non-osteoporosis group. Multiple linear regression analysis was performed to analyze the relationship between PMOF/BMI and PHF/BMI. The correlation between FRAX score and body mass index and peripheral blood calcium and phosphorus was investigated in western Guangxi patients. Results There was no correlation between clinical indicators (peripheral blood calcium, peripheral blood phosphorus, and age) and FRAX scores (PMOF and PHF) in osteoporotic population and the whole population (all P values > 0.05). There was no correlation between BMI and FRAX scores (PMOF and PHF) in osteoporotic population (P>0.05). However, there was a linear correlation between BMI and FRAX scores (PMOF and PHF) in the whole population (P<0.05). With the increase of BMI, PMOF and PHF values became smaller. Conclusion There is no significant correlation between calcium and phosphorus in peripheral blood and the risk of osteoporosis fracture in osteoporosis patients. According to the statistical analysis of this experiment, calcium and phosphorus concentration in serum cannot be used as the indicator for the diagnosis of osteoporosis fracture risk in western Guangxi patients. There is a negative correlation between BMI and PMOF and PHF in the whole population, suggesting that people with low BMI are prone to fracture. |
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