血清Asprosin水平与绝经后女性骨密度、平衡能力和骨折发生率的相关性
The Correlation between serum Asprosin levels and bone mineral density, balance ability and fracture incidence in postmenopausal women
  
DOI:10.3969/j.issn.1006-7108.2021.02.009
中文关键词:  白脂素  骨密度  骨质疏松症  平衡能力  骨折发生率
英文关键词:asprosin  bone mineral density  osteoporosis  balance ability  fracture incidence
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作者单位
夏海娥1* 陈鸿颜2 陈洪娇1 1 海南医学院第一附属医院创伤医学中心海南 海口 570102 2 海南医学院第一附属医院核医学科海南 海口 570102 
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中文摘要:
      目的 探讨血清Asprosin(白脂素)水平与绝经后女性骨密度(bone mineral density, BMD)、平衡能力和骨折发生率的相关性。方法 回顾性分析海南医学院第一附属医院收治的164例绝经后女性骨质疏松症(osteoporosis, OP)患者的临床资料。记录患者一般临床资料以及骨折发生率、髋部骨密度、平衡指数评分(BIS),前后比(FBR)和左右比例(RLR)。分析白脂素与BMD、BIS、FBR、RLR以及骨折发生率的相关性。结果 非骨折组血清白脂素水平为(3.56±0.54)pg/mL,骨折组血清白脂素水平为(6.56±1.01)pg/mL,两组血清白脂素水平比较差异有统计学意义(P<0.05);Spearman试验结果显示,白脂素与BIS、FBR和RLR及BMD呈负相关(P<0.05);白脂素与年龄(r = 0.384)、身高(r = 0.343)、体质量指数(r = 0.181)和髋部BMD显著相关(r = 0.387),但与体重无显著相关性(r = 0.022,P>0.05)。Logistic回归分析与线性回归分析显示,髋部BMD、身高、年龄和体质量指数是影响白脂素的独立因素。结论 白脂素可能是绝经后女性出现骨密度降低和平衡能力下降及出现骨折的危险因子,与髋部BMD、身高、年龄和体质量指数密切相关。
英文摘要:
      Objective To explore the correlation between serum asprosin levels and bone mineral density (BMD), balance ability and fracture incidence in postmenopausal women. Methods The clinical data of 164 postmenopausal women with osteoporosis (OP) admitted to our hospital were retrospectively analyzed. The patient's general clinical data as well as fracture incidence, hip bone density, balance index score (BIS), front-to-front ratio (FBR), and left-right ratio (RLR) were recorded. The correlation between asprosin and BMD, BIS, FBR, RLR and fracture incidence were analyzed. Results The serum asprosin level in the non- fracture group was (3.56±0.54) pg/mL, and the serum asprosin level in the fracture group was (6.56±1.01) pg/mL. There was a statistically significant difference in serum asprosin levels between the two groups (P<0.05); Spearman test results showed that asprosin was negatively correlated with BIS, FBR, RLR and BMD (P<0.05); asprosin and age (r=0.384), height (r=0.343), BMI (r=0.181) was significantly associated with hip BMD (r=0.387), but it had no significant association with body weight (r=0.022, P>0.05). Logistic regression analysis linear regression analysis showed that hip BMD, height, age and BMI were the independent factors affecting asprosin. Conclusions Asprosin may be a risk factor for postmenopausal women with reduced bone density, decreased balance, and fractures. It is closely related to hip BMD, height, age and BMI.
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