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| 异补骨脂素改善骨质疏松大鼠骨代谢的作用探讨 |
| Exploration of the effect of isopsoralen on bone metabolism in osteoporotic rats |
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| DOI：10.3969/j.issn.1006-7108.2021.02.012 |
| 中文关键词: 异补骨脂素 骨质疏松 骨密度 骨代谢 骨组织 |
| 英文关键词:isopsoralen osteoporosis bone mineral density bone metabolism bone tissues |
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| 中文摘要: |
| 目的 探讨异补骨脂素对骨质疏松大鼠骨代谢的改善作用和机制。方法 建模后测量治疗前后大鼠的骨密度和骨代谢水平；观察大鼠的骨组织结构改变；检测大鼠骨组织Runx 2、MMP13 mRNA及蛋白表达。结果 异补骨脂素提高了骨质疏松大鼠的骨密度，改善了骨代谢和骨组织结构，增强了骨组织Runx 2 mRNA及蛋白的表达，抑制了MMP13 mRNA及蛋白的表达，且其作用呈浓度依赖。结论 异补骨脂素可提高骨质疏松大鼠骨密度，改善其骨代谢和骨组织结构，还可上调骨组织Runx 2表达，抑制MMP13表达。 |
| 英文摘要: |
| Objective To explore the effect and mechanism of isopsoralen on bone metabolism in osteoporosis rats. Methods After modeling, the bone mineral density and bone metabolism were measured before and after treatment. Bone tissue structures were observed. Runx 2, MMP13 mRNA and protein expressions were detected. Results Isopsoralen enhanced bone mineral density of rats with osteoporosis, improved bone metabolism and bone tissue structures, enhanced the expressions of Runx 2 mRNA and protein in bone tissues, and inhibited the expressions of MMP13 mRNA and protein, and ind its effect was concentration-dependent. Conclusion Isopsoralen can enhance bone mineral density, improve bone metabolism and bone tissue structures in rats with osteoporosis, which can up-regulate the expression of Runx 2 in bone tissues and inhibit the expressions of MMP13. |
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