| Objective To explore the relationship between vitamin D and bone metabolism and blood uric acid (BUA) in patients with osteoporosis and hyperuricemia. Methods 72 cases of osteoporosis with hyperuricemia (combined disease group), 85 cases of simple osteoporosis (simple disease group) and 60 healthy persons for physical examination (healthy group) were selected. The serum level of 25 hydroxylated vitamin D3 (25-OHD3), osteocalcin (BGP), β cross-linked telepeptide of type-Ⅰcollagen (β-CTX), amino-terminal procollagen of type-Ⅰ collagen (PINP), bone specific alkaline phosphatase (BALP), tartrate resistant acid phosphatase-5b (TRACP-5b) and BUA were measured, then the relationship between 25-OHD3 and bone metabolism index and BUA in combined disease group were analyzed. Results The serum levels of 25-OHD3 and BALP in the combined disease group＜which in the simple disease group＜which in the healthy group, and the levels of BGP, β-CTX, PINP and TRACP-5b in the combined disease group＞which in the simple disease group＞which in the healthy group, and the differences were statistically significant (P<0.05). The level of BUA in the combined disease group was significantly higher than that in the simple disease group and the healthy group (P<0.05), but there was no significant difference in BUA level between the simple disease group and the healthy group (P>0.05). By Pearson correlation analysis, the 25-OHD3 level in the combined disease group was negatively correlated with BGP, β-CTX, PINP, TRACP-5b and BUA, but it was positively correlated with BALP (P<0.05). Conclusion The level of serum 25-OHD3 in osteoporosis with hyperuricemia is decreased, which is negatively correlated with BGP, β-CTX, PINP, TRACP-5b and BUA, but it is positively correlated with BALP. |