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| MC3T3-E1细胞在不同机械应力刺激下成骨表达机制的研究进展 |
| The research progress on the bone formation mechanism of MC3T3-E1 cells under different mechanical stress stimulation |
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| DOI：10.3969/j.issn.1006-7108.2021.02.026 |
| 中文关键词: MC3T3-E1细胞 机械应力 成骨 机制 |
| 英文关键词:MC3T3-E1cell mechanical stress osteogenic mechanism |
| 基金项目:国家自然科学基金（81960877） |
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| 中文摘要: |
| 机械应力是刺激骨组织生长的有效条件，它的加载和卸载通过影响成骨细胞的成骨进程和功能，以维持骨重建与动态平衡，从而对骨骼微环境和骨代谢产生重要影响。成骨样细胞系MC3T3-E1细胞作为力学刺激敏感细胞，常被用作应力环境下研究成骨机制的经典细胞。本文主要综述了5种体外不同机械应力刺激下的MC3T3-E1细胞成骨表达机制最新进展，以期阐明成骨细胞接收和传导力学刺激的转导网络,并对研究不同机械应力刺激下保持骨骼稳定和损伤重建的机制有所指导。 |
| 英文摘要: |
| Mechanical stress is an effective condition to stimulate the growth of bone tissue, and its loading and unloading affect the osteogenesis process and function of osteoblasts to maintain bone reconstruction and dynamic balance, which has an important impact on the bone microenvironment and the bone metabolism. The osteogenic cell line MC3T3-E1 cells, as the sensitive cells of mechanical stimulation, are often used as the classical cells to study the mechanism of osteogenesis in the mechanical stressenvironment.In this paper, we summarized the latest progress, which were about the osteogenic expression mechanism based 5 kinds of different mechanical stress stimulation on MC3T3-E1 cells, in order to clarify the transduction network of osteoblast receiving and transmitting mechanical stimulation, and to provide guidance for the study of the mechanism of maintaining bone stability and injury reconstruction under different mechanical stress stimulation. |
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