| The number of obese people in modern society is increasing year by year, and the number of patients with obesity-related metabolic bone disease is also increasing, which seriously endangers the health of the population.Chemerin, as a kind of adipokines, is mainly secreted by adipocytes and hepatocytes. Its circulating level is higher than that of classical adipokines such as Leptin and Adiponectin, which plays an important role in systemic metabolism and immunity. In recent years, studies have found that in the state of obesity, with the increase of peripheral adipose tissue, the adipose tissue in bone marrow also increases sharply. Chemerin, secreted by adipocytes in bone marrow directly inhibits the differentiation of osteoblasts and promotes the differentiation of osteoclasts and affects the microenvironment of bone marrow cavity by paracrine or autocrine. In this review, we will systematically review the literature on Chemerin and bone metabolism at home and abroad, and discuss the effect of Chemerin on bone metabolism and its mechanism. |