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| 含钙肾结石与骨密度之间关系的研究现状 |
| Current status of calcium-containing kidney stones and bone mineral density |
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| DOI：10.3969/j.issn.1006-7108.2021.02.029 |
| 中文关键词: 含钙肾结石 骨密度降低 骨质疏松 高钙尿 |
| 英文关键词:kidney stones bone mineral density osteoporosis hypercalciuria |
| 基金项目:河南省重点研发与推广专项（科技攻关）（182102310059） |
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| 摘要点击次数: 1893 |
| 全文下载次数: 1297 |
| 中文摘要: |
| 肾结石中最常见的类型为含钙肾结石。含钙肾结石和骨密度降低都存在钙的代谢紊乱，而导致钙流失。研究认为骨密度降低是肾结石形成的危险因素，含钙肾结石与骨密度降低存在潜在关系。在调查中发现，肾小管酸中毒、基因（CLDN14和CYP24A1）、骨桥蛋白、细胞因子和雌激素缺乏等因素在两者中共同存在，但两者之间的关系暂无研究予以说明。本文主要通过相关因素对含钙肾结石与骨密度之间的潜在关系进行阐述，希望对未来关于两者之间的研究和临床诊疗提供一些必要的帮助。 |
| 英文摘要: |
| The most common type of kidney stone is calcium-containing kidney stones. Calcium- containing kidney stones and decreased bone mineral density have calcium metabolic disorders, which lead to calcium loss. Studies have shown that decreased bone mineral density is a risk factor for the formation of renal stones, and there is a potential relationship between calcium-containing renal stones and decreased bone mineral density. In the investigation, it was found that renal tubular acidosis, gene (CLDN14 and CYP24A1), osteopontin, cytokiness and estrogen deficiency co-exist between them, but the relationship between them has not been specifically explained. This article mainly expounds the potential relationship between calcium-containing kidney stones and bone mineral density through related factors, hoping to provide some necessary help for the future research and clinical diagnosis and treatment between them. |
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