| Objective Our aim is to investigate the expression and significance of differential expressed long-chain non-coding RNAs and oncostatin M (OSM) in postmenopausal osteoporosis. Methods Based on the detection of lncRNAs with lncRNA-mRNA chip and co-expression analysis, the target genes lncRNA TTC28-AS1, linc-IRF2BP2-1, and linc-FAM126B-1 were analyzed with a blat software. The secondary structure of lncRNAs was predicted with an online software RNAfold. The subjects were randomly selected from the postmenopausal women, and their BMD was measured. Twenty-five women with normal BMD were included in the control group. Twenty-five patients with osteoporosis were included in the osteoporosis group. The expression of oncostatin M and lncRNA TTC28-AS1, linc-IRF2BP2-1, and linc-FAM126B-1 in the two groups were detected with quantitative PCR. Results Blat software predicted that the target of lncRNA TTC28-AS1, linc-IRF2bp2-1, and linc-FAM126B-1 was OSM, and the correlation coefficients were 0.8506 (P = 0.0037), 0.9314 (P = 0.0003), and 0.9222 (P = 0.0004) respectively. RNAfold predicted that all the 3 lncRNAs had multiple stem rings and multi-branched internal ring structures. The expression levels of OSM, lncRNA TTC28-AS1, linc-IRF2bp2-1, and linc-FAM126B-1 in postmenopausal osteoporosis group were significantly lower than those in the control group (P < 0.05). Conclusion The down-regulation of lncRNA TTC28-AS1, linc-IRF2BP2-1, linc-FAM126B-1, and their target gene oncostatin M may be related to postmenopausal osteoporosis. |