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| 血清SM4D水平与绝经后骨质疏松症患者骨密度和骨代谢指标的相关性研究 |
| Correlation between serum SM4D level and bone mineral density and bone metabolism indexes in postmenopausal osteoporosis patients |
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| DOI：10.3969/j.issn.1006-7108.2021.03.015 |
| 中文关键词: SM4D 绝经后骨质疏松症 骨密度 骨转换 |
| 英文关键词:SM4D postmenopausal osteoporosis bone mineral density bone turnover |
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| 中文摘要: |
| 目的 探讨绝经后骨质疏松症（postmenopausal osteoporosis ,POP）患者血清4D同型二聚体(SM4D)水平与骨密度（bone mineral density ,BMD）和骨转换指标的关系。方法 通过双能X线吸收测定法对257例POP患者和90例健康对照者进行BMD测量。通过酶联免疫吸附测定法测定受试者血清SM4D、BAP、BGP和TRACP-5b水平。使用自动电化学发光系统测量I型血清交联N端肽（NTX）、25-羟基维生素D[25（OH）D]和骨钙素的N-mid片段水平（N-MID-OT）。结果 与健康对照组相比，POP妇女的SM4D水平显著升高[（1.40±0.33）μg/L vs. (0.58±0.18) μg/L，P=0.006）]。SM4D水平与血清TRACP-5b和NTX水平呈正相关，与腰椎和股骨颈BMD、血清BAP和BGP水平呈负相关。SM4D水平与年龄、体质量指数以及血清25（OH）D和N-MID-OT水平之间无相关性。腰椎和股骨颈骨密度 (β= –0.354，P<0.001; β= –31.234，P<0.001)和血清BAP水平（β= 0.127，P=0.019）是POP患者血清SM4D水平的独立预测因子。结论 绝经后骨质疏松症女性SM4D与骨密度和骨转换指标密切相关。 |
| 英文摘要: |
| Objective To investigate the association of serum semaphorin 4D (SM4D) levels with bone mineral density (BMD) and bone turnover markers in patients with postmenopausal osteoporosis (POP). Methods BMD was measured by dual-energy X-ray absorptiometry in 257 POP patients and 90 healthy controls. Serum SM4D, BAP, BGP and TRACP-5b levels were measured by enzyme linked immunosorbent assay. Serum cross linked N-telopeptides of type I (NTX), 25-hydroxyvitamin D[(25(OH)D] and N-mid fragment of osteocalcin (N-MID-OT) levels were measured using automated electrochemiluminescence system. Results SM4D level was significantly higher in POP women compared to healthy controls [（1.40±0.33）μg/L vs. (0.58±0.18) μg/L，P=0.006）]. SM4D level was positively correlated with serum TRACP-5b and NTX levels and negatively correlated with BMD and serum BAP and BGP levels. There were no correlations between SM4D level and age, body mass index, and serum 25(OH)D and N-MID-OT levels. BMD of lumbar spine and femoral neck (β= – 0.354，P<0.001; β= –31.234，P<0.001) and serum BAP level（β= 0.127，P=0.019）were the independent predictors of serum SM4D level in POP patients. Conclusions The SM4D and bone turnover indexes are closely related to bone density in postmenopausal women with osteoporosis. |
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