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| 血清胃饥饿素水平与绝经后骨质疏松症合并代谢综合征患者骨密度相关性研究 |
| Correlation between ghrelin and bone mineral density in postmenopausal osteoporotic patients with metabolic syndrome |
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| DOI：10.3969/j.issn.1006-7108.2021.03.017 |
| 中文关键词: 绝经后骨质疏松症 尿戊糖素 骨代谢指标 骨密度 代谢综合征 |
| 英文关键词:postmenopausal osteoporosis, urinary pentosaccharide, bone metabolic index, bone mineral density metabolic syndrome |
| 基金项目:河北省卫生健康委医学科学研究课题（20171214） |
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| 中文摘要: |
| 目的 探索胃饥饿素与绝经后骨质疏松症合并代谢综合征患者骨密度相关性。方法 本研究纳入我院初诊未经治疗的绝经后骨质疏松症患者(T评分 |
| 英文摘要: |
| Objective To explore the relationship between ghrelin and bone mineral density (BMD) in patients with postmenopausal osteoporosis complicated with metabolic syndrome. Methods The study included untreated postmenopausal osteoporosis patients (T score <-2.5) who were newly diagnosed in our hospital. A total of 320 female postmenopausal osteoporotic subjects were included. There were 78 patients with metabolic syndrome, and 242 women without metabolic syndrome. Enzyme-linked immunosorbent assay was used to determine the levels of serum ghrelin and bone metabolism indexes. The BMD of the lumbar spine (L1-L4) and femoral neck of each research subject was measured with dual-energy X-ray bone absorptiometry. Pearson correlation analysis was used for correlation analysis between the variables. Results The height, weight, BMI, blood glucose, lumbar spine (L1-L4), triglycerides, blood glucose, total cholesterol, femoral neck BMD, type I collagen amino terminal elongation peptide and β-I type collagen carboxy terminal peptide, and ghrelin levels between postmenopausal osteoporosis group (OP) and postmenopausal osteoporosis combined with metabolic syndrome group (OPMS) were significantly different (P <0.05). According to Spearman correlation analysis, serum ghrelin levels were negatively correlated with BMD. P1NP was positively correlated with β-CTX level, but was not correlated with triglycerides, blood glucose, and total cholesterol. Conclusion The increase of serum ghrelin level may be a potential risk factor for postmenopausal osteoporosis complicated with metabolic syndrome. |
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