| Objective To review the effect of different stresses on apoptosis of the osteoblast. Methods The recent researches and reviews related to the effect of various stress loading on osteoblasts were searched and analyzed. Meanwhile, the comprehensive analysis and summary were carried out. Results Apoptosis of osteoblasts is related to the occurrence and development of many bone diseases which include osteoporosis and bone loss caused by various reasons. Studies on osteoblast apoptosis may provide new ideas for the treatment of these diseases. Relevant research has confirmed that mechanical signals play an important role in osteoblast apoptosis, which may provide new ideas for clinical treatment of osteoblast-related bone diseases. Based on the existing literature, the mechanical loads used in the current research are mainly fluid shear stress, stretch stress, and hydrostatic pressure. The main research directions include the inhibition or promotion of various stresses on osteoblast apoptosis, the effect of loading time and intensity on osteoblast apoptosis, and the subcellular mechanism of the effect of mechanical signals on osteoblast apoptosis. Conclusion Through a comprehensive analysis of related literature, it can be considered that the effect of the three mechanical signals on osteoblasts is similar. According to the analysis of the research data, the effect of the three mechanical signals on the osteoblast apoptosis exists with time and intensity, i.e., transformation phenomenon from anti-apoptotic to pro-apoptotic. In the current research, the use of fluid shear stress and tensile stress to provide mechanical signals is more complete, and the use of hydrostatic pressure type is less and incomplete, which needs to be supplemented in future research. |