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| 系统性红斑狼疮相关骨质疏松危险因素的研究进展 |
| Research progress in the risk factors of systemic lupus erythematosus-related osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2021.03.024 |
| 中文关键词: 系统性红斑狼疮 骨密度 骨质疏松 危险因素 |
| 英文关键词:systemic lupus erythematosus bone mineral density osteoporosis risk factors |
| 基金项目:潍坊市科技发展计划项目（2019YX094）；潍坊市卫健委科研项目（wfwsjk-2019-167） |
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| 中文摘要: |
| 系统性红斑狼疮（SLE）是累及多个系统的自身免疫性疾病，患者大多是年轻女性，病程较难预测，常常是病情缓解和病情活动交替出现。临床上，SLE合并骨质疏松并不少见，其病理机制复杂，尚无确切定论。骨质疏松也是SLE疾病的并发症之一，但并非单纯由糖皮质激素治疗等原因导致。近年来研究发现，SLE患者骨密度减低与疾病活动和病情进展有关，疾病相关炎症反应、代谢、内分泌、自身抗体、遗传因素及药物影响均参与骨质疏松的发生。因此，本文对SLE相关骨质疏松的研究进展做一综述。 |
| 英文摘要: |
| Systemic lupus erythematosus (SLE) is an autoimmune disease that damages multiple systems. Most of the patients are young women. The course of SLE is difficult to predict. The remission and active phase of the disease often occur alternatively. SLE with osteoporosis is not uncommon in clinical practice. The pathological mechanism is complex and there is no definite conclusion. Osteoporosis is also one of the complications of SLE, but it is not caused by glucocorticoid therapy alone. Recent studies have found that the decrease of bone mineral density in SLE patients is related to disease activity and progression. Disease-related inflammatory reaction, metabolism, endocrine, autoantibody, genetic factors, and drug use are involved in the occurrence of osteoporosis. Therefore, this article reviews the research progress of SLE-related osteoporosis. |
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