| As the social population gradually ages, the incidence of osteoporosis increases year by year. Due to the increasing social pressure and changes in lifestyle, people’s sleeping problems are becoming more and more obvious. Current research shows that there is a correlation between the two. Changes in secretion levels of melatonin and glucocorticoids caused by abnormal sleeping, increased concentrations of inflammatory factors such as IL-6 and TNF-α, changes in the expression of clock genes such as Bmal1 and Clock, and the occurrence of oxidative stress, can affect bone metabolism, reduce bone mineral density, and even cause osteoporosis. This article reviews the relationship between sleep and osteoporosis in recent years from four perspectives: circadian rhythm disturbance, sleep time change, sleep apnea and sleep medication, and explores the possible correlative mechanism between various sleep problems and osteoporosis. |