| Objective To investigate the skeletal phenotype of type 2 diabetic mice with Leptin receptor (Lepr) deficiency and to provide a new target for the prevention and treatment of type 2 diabetes mellitus (T2DM) combined with osteoporosis (OP). Methods Get 20 males only 14 weeks of db/db mice (lack of leptin receptor) in mice and wild-type mice (C57BL mice) shin (10), through the Micro-CT detection to compare both trabecular bone volume (BV/TV) relatively, the surface area of bone tissue volume ratio (BS/TV), bone trabecular thickness (Tb.Th), bone trabecular number (Tb. N), separating degree (Tb. Sp), trabecular bone bone structure model index (SMI), bone cortical thickness (Ct.Th), bone cortex area (Ct.Ar) bone microstructure parameters, such as difference. Results Compared with wild type mice, 14 weeks of db/db mice tibial trabecular bone volume (BV/TV) and bone trabecular thickness (Tb. Th), bone trabecular number (Tb. N) significantly reduced, trabecular bone spacing (Tb. Sp) increased, the corresponding cortical thickness (Ct.Th), cross-sectional area (Ct.Ar) decreased, and compared the differences between all had significant statistical significance (P < 0.05);The structure model index (SMI) was significantly lower than that of the wild type, and the difference between the two was statistically significant (P < 0.05). Conclusion Type 2 diabetes may affect the change of bone mass through the signal pathway involved in leptin receptor, which provides a new direction for the study of DOP etiology and treatment methods by using this model. In addition, in the absence of leptin signal transduction, bone mass and strength decrease, which proves that leptin plays a role of anabolic bone factor in the body. |