| Objective To explore the Fracture Risk Assessment Tool (FRAX) to assess the risk of osteoporotic fracture in patients with Systemic lupus erythematosus（SLE), and to analyze the correlation factors. Methods Retrospective analysis of clinical parameters and bone mineral density was performed in 90 patients with SLE and 60 normal cases in control group from January 2018 to June 2019. FRAX was used to assess the risk of osteoporotic fractures in SLE patients. According to the risk <10% and ≥10%, they were divided into the low-risk group and the high-risk group. The independent factors affecting the risk of osteoporotic fracture in SLE patients were investigated by Logistic regression analysis. Results Bone mineral density in the SLE group was significantly lower than that in the control group. The ten years risk of osteoporotic fracture in the SLE group was (9.23±2.97)%, significantly higher than that in the control group (3.09±1.04) %. In the low risk group, the fracture risk was (7.69± 0.95) %.In the high-risk group, the risk of fracture was (13.21±2.75) %. There were significant differences in age, weight, disease duration≥ 2 years, BMI, serum albumin, bisphosphonate utilization rate between the high-risk group and the low- risk group（P＜0.05）. Multivariate Logistic regression analysis showed that age ≥70, disease duration ≥2 years, and SLEDAI score ≥10 were the independent factors affecting the risk of osteoporotic fractures in the SLE patients. Conclusions The bone mineral density in the SLE patients was lower than the normal population, and the ten years fracture risk was higher than the normal population. Among them, age ≥70 , disease duration ≥2 years, and SLEDAI score ≥10 can increase the risk of fracture. |