| The prevalence of osteoporosis is increasing in China over these years. It is found that patients with liver disease are more likely to develop osteoporosis, and even further to develop osteoporotic fractures, which greatly reduce the quality of life of the patients. About 40% of patients with chronic liver disease may experience a fracture. The pathogenesis of hepatogenic osteoporosis is related to many factors including disorder of carbohydrates metabolism, fibronectin, insulin-like growth factor 1, various cytokines, the decrease of vitamin D, and the imbalance of sex hormones. This article reviews the mechanism of bone loss in patients with liver disease. |