膝骨关节炎与骨质疏松症的相关性研究进展
Research progress on the correlation between knee osteoarthritis and osteoporosis
  
DOI:10.3969/j.issn.1006-7108.2021.04.027
中文关键词:  膝骨关节炎  骨质疏松症  相关性
英文关键词:knee osteoarthritis  osteoporosis  correlation
基金项目:国家自然科学基金面上项目资助(81573996,81873327);泉州市卫生计生科研资助项目计划(2015-37)
作者单位
张程1,2 吴忠书1,2 李子祺1,3 沈莹珊1,2 庄至坤2,4 袁颖嘉3 何伟1 魏秋实 ,3* 1. 广州中医药大学骨伤科研究所广东 广州 510378 2.广州中医药大学第一临床医学院广东 广州 510405 3. 广州中医药大学第三附属医院关节科广东 广州 510378 4. 福建中医药大学附属泉州市正骨医院关节科福建 泉州 362000 
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中文摘要:
      膝骨关节炎(osteoarthritis of the knee, KOA)与骨质疏松症(osteoporosis, OP)是骨科领域两大常见疾病,且临床上两者常常同时出现。通过回顾文献,我们发现两种疾病在流行病学、病理机制及治疗等方面具有一定的关联性。认识到OP与软骨下骨吸收在KOA的病理进程中发挥着重要作用,在KOA的早期,尤其是合并有OP的KOA患者,进行抗OP治疗可能对延缓KOA的进展有一定的帮助,但目前尚需要更多的多中心大样本随机对照试验加以证明。
英文摘要:
      Knee osteoarthritis (Osteoarthritis of the knee, KOA) and osteoporosis (OP) are two common diseases in orthopaedic field, and they often occur simultaneously in clinic. Through reviewing the literature, we found that the two diseases have a certain correlation in terms of epidemiology, pathological mechanism and treatment. It is recognized that OP and subchondral bone resorption play an important role in the pathological process of KOA. In the early stage of KOA, especially in KOA patients with combined OP, anti-op therapy may be helpful to delay the progress of KOA, but more multicentre large sample randomized controlled trials are still needed to prove it at present.
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