中国骨质疏松杂志

2型糖尿病患者晚期糖基化终末代谢产物与骨代谢的相关性

Correlation between advanced glycation end-products and bone metabolism in type 2 diabetes patients

DOI：10.3969/j.issn.1006-7108.2021.05.003

英文关键词:type 2 diabetes mellitus advanced glycation end-products bone metabolism

基金项目:国家自然科学基金青年基金（81900746）

作者	单位
孙建然1 祝捷1 赵兵1 章诗琪2 邓大同2 潘发明3 叶山东1 陈超1*	1.中国科学技术大学附属第一医院内分泌科，安徽合肥 230001 2.安徽医科大学第一附属医院内分泌科，安徽合肥 230022 3.安徽医科大学公共卫生学院，安徽合肥 230032

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中文摘要:

目的观察2型糖尿病（type 2 diabetes mellitus，T2DM）患者中，经皮肤测得的晚期糖基化终末代谢产物（advanced glycation end-products，AGEs）与骨代谢的相关性。方法根据AGEs水平将306例T2DM患者分成3组(T1：AGEs＜80 AU，T2：80 AU≤AGEs＜100 AU，T3：≥100 AU），其中T1组180例，T2组107例，T3组19例。采用双能X线吸收测定法测定股骨颈和腰椎1～4的骨密度，用电化学发光免疫分析测定骨转化指标。结果 AGEs与I型胶原C端肽无相关性（r=-0.006，P=0.923），与骨钙素呈负相关（r=-0.14，P =0.026）。校正可能的混杂因素后，与T1组相比，T3组和T2组发生骨质疏松的危险度分别增加58%和14%。结论 AGEs可能通过抑制成骨细胞的活动，对T2DM患者的骨代谢发挥一定的损害作用。

英文摘要:

Objective To investigate the correlation between advanced glycation end-products (AGEs) detected by skin autofluorescence and bone metabolism in type 2 diabetes mellitus (T2DM). Methods A total of 306 T2DM patients were divided into three groups (T1, AGEs<80 AU; T2, 80 AU≤AGEs<100 AU; and T3, AGEs≥100 AU) according to the AGEs level on the skin. There were 180, 107, and 19 subjects in group T1, T2, and T3, respectively. Bone mineral density of the femur neck and lumbar vertebrae 1–4 were measured with dual-energy X-ray absorptiometry. Bone turnover biomarkers were detected with electrochemiluminescence method. Results No correlation was found between AGEs and collagen type Ⅰ β-crosslinked C-telopeptide (r=?0.006, P=0.923). AGEs were negatively correlated with osteocalcin (r=?0.14, P=0.026). After adjusting for multiple confounders, further analysis revealed that compared with the T1 group, the odds for osteoporosis increased by 58% and 14% in the T3 and T2 groups, respectively. Conclusion AGEs may negatively impact bone metabolism by inhibiting osteoblast activity in T2DM patients.

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