| Objective This paper investigates the risk factors of diabetic osteoporosis (DOP) and provides the guidance for the further treatment. Methods From June 2019 to December 2019, 134 patients with type 2 diabetes (75 males and 59 females) were collected. They were divided into 3 subgroups: normal BMD subgroup (Group A), osteopenia subgroup (Group B), and osteoporosis subgroup (Group C). The clinical data (sex, age, diabetes duration, waistline, and BMI) and laboratory parameters (Ca, P, ALP, FPG, GSP, HbA1c, TC, HDL-C, LDL-C, TG, β-CTx, P1NP, 25(OH)D3, PTH, OC, FCP, and CT) were compared among the 3 groups. Results The age, waistline, BMI, P, TG, TC, LDL-C, GSP, HbA1c, P1NP, 25(OH)D3, and OC were significantly different among the 3 subgroups (P<0.05). Waistline, 25(OH)D3, P1NP, and OC were negatively correlated with BMD (P<0.05). P, HbA1c, and β-CTx were positively correlated with BMD (P<0.05). In the binary logistic regression analysis, P1NP and β-CTx were influential factors, P1NP was a protective factor (OR=0.946, P<0.05), and β-CTx was a risk factor (OR=1.012, P<0.001). Conclusion P1NP and β-CTx are influential factors of DOP. P1NP is a protective factor of DOP. β-CTx is a risk factor of DOP. |