|
| 北京地区中老年男性骨硬化蛋白与心血管危险因素的关系 |
| Relationship between sclerostin and cardiovascular risk factors in middle-aged and elderly men in Beijing |
| |
| DOI：10.3969/j.issn.1006-7108.2021.05.006 |
| 中文关键词: 骨硬化蛋白 年龄 体质量指数 |
| 英文关键词:sclerostin age body mass index |
| 基金项目:国家老年疾病临床医学研究中心开放课题（NCRCG-PLAGH-2019016）；军队保健专项科研课题（19BJZ29） |
|
| 摘要点击次数: 460 |
| 全文下载次数: 439 |
| 中文摘要: |
| 目的 在北京地区中老年男性正常血糖人群中，分析骨硬化蛋白与心血管危险因素之间的关系。方法 从北京某社区中老年人群横断面调查中筛查出糖代谢正常男性共105例(40～69岁)进行问卷调查。收集年龄、吸烟饮酒史、既往史等信息。测量体质量指数（BMI）、腰围、血压等。化验血糖、血脂，酶联免疫吸附法（ELISA）测定血清骨硬化蛋白水平。结果 ①不同年龄、BMI的研究对象血清骨硬化蛋白水平差异有统计学意义（P＜0.05）；②年龄、BMI与骨硬化蛋白水平之间有相关性；③多元线性回归分析显示骨硬化蛋白与年龄、BMI显著相关。结论 在众多心血管危险因素中，年龄、BMI与骨硬化蛋白水平呈正相关。 |
| 英文摘要: |
| Objective To analyze the relationship between sclerostin and cardiovascular risk factors in middle-aged and elderly men with normal blood glucose in Beijing. Methods One hundred and five men (40-69 years old) with normal glucose metabolism were screened from a cross-sectional survey of middle-aged and elderly population in a community in Beijing. Age, smoking and drinking history, history of past illness, and other information were collected. Body mass index (BMI), waist circumference, and blood pressure were measured. Blood glucose and blood lipids were tested. Serum sclerostin level was determined using enzyme-linked immunosorbent assay (ELISA). Results 1) The level of sclerostin was statistically different among subjects of different age and BMI (P<0.05). 2) There was a correlation between age, BMI, and sclerostin. 3) The multivariate linear regression analysis showed that sclerostin was significantly correlated with age and BMI. Conclusion Among many cardiovascular risk factors, age and BMI were positively correlated with the level of sclerostin. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |