| Objective To explore the relationship between helicobacter pylori (Hp) infection and osteoporosis. Methods The related literatures about the relationship between Hp and osteoporosis, serum calcium, alkaline phosphatase, and vitamin D were searched in PubMed, Springer Link, Web of Science, China knowledge Network, and Wanfang database from the establishment of the database to July 2020. The data were extracted by two reviewers. meta-analysis, Q test, and I2 test were used to evaluate the heterogeneity with a Stata15.0 software. When there was heterogeneity, subgroup analysis was used to find the source of heterogeneity. The random effect model was used to calculate RR and 95% CI. The fixed effect model was used otherwise. Results A total of 23 articles were included. Meta-analysis showed that Hp infection increased the incidence of osteoporosis and there was significant difference (RR:1.45, 95%CI:1.22, 1.72). Subgroup analysis showed that there was significant difference between the elderly and females, but there was no significant difference between males and general population. Hp infection reduced the level of bone mineral density and there was a statistical difference (SMD:-2.16, 95%CI:-3.96,-0.36). Hp infection affected the level of vitamin D and there was a significant difference (SMD:-0.70, 95%CI:-1.13, -0.27). However, there was no significant difference in serum calcium and alkaline phosphatase. Conclusion Hp infection may promote the occurrence of osteoporosis and decrease the levels of bone mineral density and vitamin D. More attention should be paid to the treatment of Hp in patients with osteoporosis. |