| Objective By measuring the levels of thyroid stimulating hormone (TSH) and related biochemical markers of bone metabolism in elderly patients with osteoporosis, this paper proposes to study their correlation with spinal fractures. Methods From January 2018 to December 2019, the elderly patients over 60 years old who met the diagnostic criteria of osteoporosis and subclinical thyroid dysfunction in our orthopedic department were selected. They were divided non-fracture group (group A) and fracture group (group B). Serum levels of TSH, BGP, t-PINP, β-CTX, and 25(OH)D were determined with electrochemical luminescence method. Results TSH and BGP contents in group B were lower than those in group A, and t-PINP/β-CTX in group B was higher than that in group A. The differences were statistically significant (P<0.05). Bivariate correlation analysis showed that the elderly osteoporotic spinal fracture was negatively correlated with TSH and BGP (r=-0.195, -0.133, PALL<0.05), positively correlated with t-PINP/β-CTX (r=0.371, P<0.05), and uncorrelated with β-CTX, t-PINP, 25(OH)D, and BGP/β-CTX (r=-0.195, -0.133, PALL<0.05). The AUC of TSH combined with t-PINP/β-CTX ratio was 0.825, which was the highest compared to that of TSH and t-PINP/β-CTX, and the difference was statistically significant (P<0.05). The sensitivity, specificity, positive predictive value, and negative predictive value were 81.99%, 70.05%, 79.3%, and 73.6%, respectively. Conclusion Serum TSH level and t-P1NP/β-CTX ratio are significantly related to the elderly osteoporotic spinal fractures, which can predict the occurrence of spinal fractures in the elderly. |