| Objective To explore the significance of serum anti-cyclic citrullinated peptide antibody (anti-CCP), anti-mutated citrullinated vimentin (MCV) antibody, glucose-6-phosphate isomerase (GPI) antigen, rheumatoid factor (RF), serum matrix metalloproteinases-3 (MMP-3), anti-RA33, and serum amyloid A (SAA) in the diagnosis of rheumatoid arthritis (RA). Methods One hundred and sixty patients with early RA, 100 patients with non-RA rheumatism, and 100 healthy persons were selected. The above mentioned 7 serum markers were detected. The positive rates of each index were counted and statistically analyzed. Results The average levels of serum anti-CCP, anti-MCV, GPI antigen, RF, MMP-3, anti-RA33, and SAA were markedly higher in early RA group than those in non-RA rheumatism group and healthy control group. There was statistical difference in the positive rates among the 3 groups (P<0.05). In early RA group, the sensitivity of anti-MCV was the highest (86.25%), followed by anti-CCP (83.50%), GPI antigen (83.50%), and RF (81.00%). Combined with specificity, Youden Index, positive predictive value, and negative predictive value, anti-CCP, anti-MCV, GPI antigen, and RF had better diagnostic value, MMP-3 had medium value, and anti-RA33 and SAA had poor values. Combination detection with anti-CCP, anti-MCV, GPI antigen, and RF had the highest specificity (99.50). Conclusion The single detection with anti-CCP, anti-MCV, GPI antigen, or RF has better diagnostic ability for early RA. The combination detection with the 4 markers is suitable for the early diagnosis and differential diagnosis of RA. |