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| 抗MCV抗体与RANKL、OPG、TRACP-5b及RA疾病活动度的相关性研究 |
| Correlation between anti-MCV antibodies and RANKL, OPG, TRACP-5b, and RA disease activity |
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| DOI：10.3969/j.issn.1006-7108.2021.05.018 |
| 中文关键词: 类风湿关节炎 抗突变型瓜氨酸波形蛋白 核因子κB受体活化因子配体 骨保护素 抗酒石酸酸性磷酸酶5b |
| 英文关键词:rheumatoid arthritis anti-mutant citrullin vimentin nuclear factor kappa B receptor activating factor ligand osteoprotegerin tartrate-resistant acid phosphatase 5b |
| 基金项目:湖南省自然科学基金（青年基金）项目（2017JJ3532） |
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| 中文摘要: |
| 目的 探索类风湿关节炎（rheumatoid arthritis，RA）患者抗突变型瓜氨酸波形蛋白（mutant citrulline vimentin，MCV）抗体与骨代谢标志物及疾病活动度之间的关系。方法 收集119例RA患者临床资料和血清，检测抗MCV抗体及RANKL、OPG和TRACP-5b等骨代谢标志物，分析抗MCV抗体与骨代谢标志物之间的相关性，并探索抗MCV抗体与疾病活动是否有关联。结果 ①RA患者抗MCV抗体滴度与RANKL、TRACP-5b水平及RANKL/OPG均无显著相关性（P＞0.05），与OPG呈正相关但相关系数低（r=0.183，P＜0.05）。②抗MCV抗体与DAS28（r=0.376，P＜0.01）、ESR（r=0.440，P＜0.01）、RF-IgM（r=0.376，P＜0.01）呈正相关。结论 抗MCV抗体与血清中骨代谢相关标志物TRACP-5b、RANKL、OPG、RANKL/OPG均无显著相关性，提示抗MCV抗体可能不直接通过影响骨代谢参与RA骨侵蚀进展。抗MCV抗体与疾病活动度呈正相关，提示它对RA病情评估可能有一定的价值。 |
| 英文摘要: |
| Objective To explore the relationship among anti-mutant citrulline vimentin (MCV) antibody, bone metabolic markers, and disease activity in patients with rheumatoid arthritis (RA). Methods The clinical data and serum of 119 RA patients were collected. Anti-MCV antibody and bone metabolism markers such as RANKL, OPG, and TRACP-5b were detected. The correlation between anti-MCV antibody and bone metabolism markers was analyzed, and the relationship between anti-MCV antibody and disease activity was explored. Results 1) There was no significant correlation between the titer of anti-MCV antibody and the levels of RANKL, TRACP-5b, and RANKL/OPG in RA patients (P>0.05). The correlation between titer of anti-MCV antibody and OPG was positive but with low correlation coefficient (r=0.183, P<0.05). 2) Anti-MCV antibody was positively correlated with DAS28 (r=0.376, P<0.01), ESR (r=0.440, P<0.01), and RF IgM (r=0.376, P<0.01). Conclusion There is no significant correlation between anti MCV antibody and serum markers of bone metabolism, such as TRACP-5b, RANKL, OPG, and RANKL/OPG, suggesting that anti-MCV antibody may not directly participate in the development of RA bone erosion by influencing bone metabolism. There is a positive correlation between anti-MCV antibody and disease activity, suggesting that it may have some value in the evaluation of RA. |
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