|
| 从中医“虚”论治原发性骨质疏松症与OPG/RANK/RANKL信号通路的相关性 |
| The relationship between the treatment of primary osteoporosis and OPG/RANK/RANKL signaling pathway based on "deficiency" of Chinese medicine |
| |
| DOI：10.3969/j.issn.1006-7108.2021.05.023 |
| 中文关键词: 中医学 虚证 原发性骨质疏松症 OPG/RANK/RANKL信号通路 |
| 英文关键词:traditional Chinese medicine deficiency syndrome primary osteoporosis OPG/RANK/rank signal pathway |
| 基金项目:国家自然科学基金项目(81860864)；中央引导地方科技发展专项项目-甘肃地区多发病防治能力提升创新平台项目；兰州市科技局社会发展项目(2016-3-102)；甘肃省属科研院所基础条件建设专项(18JR2TA016)；国家中医药管理局中医临床研究基地业务建设专项(JDZX2015080)；甘肃省科技计划资助（20JR5RA129）；甘肃省省级引导科技创新发展专项资金项目 |
|
| 摘要点击次数: 488 |
| 全文下载次数: 441 |
| 中文摘要: |
| 原发性骨质疏松症（primary osteoporosis，POP）是现代临床中常见的骨科疾病，其归属于中医学之“骨痿”“骨痹”“骨枯”等范畴。随着中医药事业的发展，中医学在POP的治疗中应用愈加广泛，且疗效显著，已受到学界的广泛认可。但遗憾的是，其缺乏现代研究理论依据的支撑。随着分子生物学的发展，OPG/RANK/RANKL信号通路的发现对中医学治疗此病具有重要意义。故笔者将从中医“虚”理论出发，并以中医学脏腑辨证理论为基础，借助现代分子生物学的研究成果OPG/RANK/RANKL信号通路，揭示中医治疗POP的OPG/RANK/RANKL信号通路表达机制，以期为中医学治疗POP提供科学理论依据。 |
| 英文摘要: |
| Primary osteoporosis (POP) is a common orthopedic disease in modern clinic, which belongs to the categories of "bone flaccidity", "bone arthralgia", and "bone dryness" in traditional Chinese medicine. With the development of Chinese medicine, Chinese medicine has been widely used in the treatment of POP. Its efficacy is remarkable, which has been widely recognized in academics. Unfortunately, it lacks the support by modern research theory. With the development of molecular biology, the discovery of OPG/RANK/RANKL signaling pathway is of great significance to the treatment of this disease with traditional Chinese medicine. Therefore, the authors reveal the OPG/RANK/RANKL signal pathway expression mechanism of treatment of POP with traditional Chinese medicine from the "deficiency" theory, and based on the syndrome differentiation theory of viscera in traditional Chinese medicine, and with the help of modern molecular biology research in OPG/RANK/RANKL signal pathway, in order to provide scientific theoretical basis for traditional Chinese medicine for the treatment of POP. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |