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| 组蛋白修饰在破骨细胞分化中的作用 |
| The role of histone modification in osteoclast differentiation |
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| DOI：10.3969/j.issn.1006-7108.2021.05.025 |
| 中文关键词: 组蛋白修饰 破骨细胞 小分子抑制剂 |
| 英文关键词:histone modification osteoclast small molecule inhibitor |
| 基金项目:国家自然科学基金（81760160）；江西省教育厅项目(GJJ180809)；赣南医学院校级课题（YB201901） |
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| 中文摘要: |
| 破骨细胞（osteoclast，OC）是来源于造血干细胞的多核巨细胞，是机体内唯一具有骨吸收功能的细胞。OC功能失衡与多种骨代谢疾病的发生发展密切相关，如骨质疏松症、骨关节炎和Paget’s病等，常作为骨代谢疾病临床治疗和药物研发的靶细胞。组蛋白（histone，H）是细胞核内序列高度保守的蛋白质，组蛋白修饰是指组蛋白在酶作用下发生甲基化、乙酰化、磷酸化、腺苷酸化和泛素化等修饰的过程，组蛋白修饰通过影响染色质的结构和松弛程度，调控基因转录和翻译，从而影响相关疾病的发展。近年来，越来越多的研究表明组蛋白修饰对于破骨细胞的分化具有重要的调节作用。本文对组蛋白修饰在破骨细胞分化中的作用进行综述，为组蛋白修饰抑制剂在骨代谢相关疾病中的研发和临床运用提供指导。 |
| 英文摘要: |
| Osteoclasts (OCs) are multinucleated giant cells derived from hematopoietic stem cells and are the only cells that have bone resorption function in the body. The imbalance of OCs function is closely related to the occurrence and development of a variety of bone metabolic diseases, such as osteoporosis, osteoarthritis, and Paget’s disease. OCs are often used as target cells for clinical treatment and drug development. Histone is a highly conserved protein in the nucleus. Histone modification refers to the process of methylation, acetylation, phosphorylation, adenylation, and ubiquitination under the function of enzymes. Histone modification affects the development of related diseases by affecting chromatin structure and relaxation and by regulating gene transcription and translation. In recent years, more and more studies have shown that histone modification plays an important regulatory role in osteoclast differentiation. This article reviews the role of histone modification in osteoclast differentiation, providing guidance for the development and clinical application of histone modification inhibitors in bone metabolic diseases. |
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