| Objective To investigate the influence of diabetic microangiopathy on bone mineral density (BMD) and bone metabolic markers and provide scientific evidence for prevention of osteoporosis (OP). Methods Our study included 457 type 2 diabetes mellitus (T2DM) patients(≥50 years) admitted to the Department of Endocrinology of Perking University Shenzhen Hospital from December 2018 to December 2019. According to the diabetic microangiopathy, which involved diabetic neuropathy(DN), diabetic retinopathy(DR) and diabetic peripheral neuropathy(DPN), patients were divided into group A (160 patients without diabetic microangiopathy), group B (297 patients with diabetic microangiopathy) to compare the BMD and bone metabolic markers. Results Compared with group A, the BMD, T-value and Z-value of lumbar vertebraeL1-4, femoral neck and femur were lower in group B, the level of lab results (β-CTX, PINP, N-MID)were higher and the level of lab results [24 h urine Ca, 25(OH)D3]were lower (P<0.05). The prevalence of OP in T2DM patients with diabetic microangiopathy was higher (8.8 % vs 20.9 %, OR=2.156; 95% CI: 1.102-4.220, P＜0.05). Conclusion When T2DM was complicated with diabetic microangiopathy, the expression of bone formation markers and bone resorption markers increased, the rate of bone turnover accelerated. The level of PTH increased and the activity of osteoclasts increased, BMD decreased while the prevalence of OP increased. |