| Objective The purpose of this study is to explore the risk factors of osteoporosis in patients with Parkinson's disease (PD) and the relationship between osteoporosis and non-motor symptoms of PD. Methods 58 PD patients and 63 healthy people were studied, including 25 cases of PD with osteoporosis and 33 cases of PD without osteoporosis. The bone mineral density (BMD) and serum 25- hydroxyvitamin D(25OHD) levels of lumbar vertebrae and femoral neck of all subjects were detected. The age, sex, body mass index, levodopa equivalent daily dose (LED) and serum homocysteine (Hcy) levels of PD patients were collected, and they were evaluated by the International Association for Motor Disorders Unified Parkinson's Disease Rating Scale III (MDS-UPDRS III), Hoehn-Yahr Stage (H-Y Stage) and scored for non-motor symptoms such as emotion, cognition and sleep. Results In PD group, BMD of femoral neck, total BMD of lumbar spine and 25OHD were lower than those in control group, while osteoporosis rate and 25OHD deficiency rate were higher than those in control group (P < 0.05). Female, equivalent daily dose of levodopa, hyperhomocysteinemia, late H-Y stage and low body mass index are the risk factors of osteoporosis in PD. Emotion, cognition, sleep and other non-motor symptoms are not related to osteoporosis in PD patients. Conclusion PD patients are a high-risk group with osteoporosis. Intervention measures should be taken to reduce the disability and mortality rate according to the related risk factors of osteoporosis. |