| Glucocorticoid is a common anti-inflammatory drug. Long-term use of glucocorticoid leads to osteoporosis, increases the incidence of fracture, and seriously affects the quality of life of patients. By regulating the expression of genes and proteins in Wnt/β-catenin, OPG/RANK/RANKL, BMP/Smad, AKT, ERK and other signaling pathways, the drugs can affect the proliferation and differentiation of osteoblasts and osteoclasts, regulate the process of bone formation and bone absorption, and play a role in the treatment of GIOP. In this paper, the pathogenesis and drug action mechanism of glucocorticoid-induced osteoporosis are summarized. Western drugs include vitamin D and calcium, bisphosphonates, parathyroid hormone and Denosumab which are commonly used in the clinic. Chinese herbs include Icariin, Rehmanniae Radix Preparata, Geniposide, Morinda officinalis and Plastrum testudinis. |