| Objective To investigate the correlation between sarcopenia and peripheral inflammatory markers. Methods The PubMed, Web of Science, CINAHL, Cochrane Library, CNKI, CBM, VIP, and Wanfang databases were selected as data sources. The studies about the peripheral inflammatory markers in sarcopenia patients from the time of database establishment to May 2020 were collected. The literature screening and data extraction were independently completed by two researchers. The JBI critical appraisal tool and the Newcastle-Ottawa Scale were used to evaluate the methodological quality of included literatures. Revman 5.3 and Stata12.0 software were used for statistical analysis. Results Seventeen literatures involving 26726 samples were included, including 9826 patients and 16900 normal people. The inflammatory markers involved were CRP, IL, TNF-α, IL-8, and IL-10. Meta-analysis indicated that CRP (MD = 0.20, 95% CI 0.15 - 0.24, P<0.00001) and IL-6 (MD = 0.77, 95% CI 0.13 - 1.40) P=0.02) were higher in sarcopenia group than in normal control group. The levels of TNF-α, IL-8, IL-10 were not statistically different between the two groups. Conclusion The levels of CRP and IL-6 may be related to the occurrence and development of sarcopenia. Large amount of samples and high quality evidence are needed to confirm the feasibility of taking them as biomarkers of sarcopenia in the future. |