| Objective To investigate the relationship between serum lipid, bone metabolism and bone metabolism density (BMD) in postmenopausal patients with type 2 diabetes mellitus (T2DM) treated with diet and exercise only. Methods A total of 105 patients with T2DM treated in the Department of Endocrinology, People's Hospital of Ningxia Hui Autonomous Region from January 2018 to January 2020 were enrolled. Their ages were from 45 to 70 years old. The course of diabetes, height, weight, body mass index (BMI), serum lipid (TC, TG, HDL, LDL), and glycosylated hemoglobin (HbA1c) were recorded. BMD of the lumbar spine (L1-4), femoral Neck (neck), trochanter (Troch), and Ward triangle (Wards) of the subjects were measured with dual energy X-ray absorptiometry and were statistically analyzed. Results With the increase of age, BMD showed a downward trend. Age, course of disease, glycosylated hemoglobin, TG, LDL, PTH, OC, TPINP, and β-CTX were negatively correlated with BMD in various parts. BMI and 25-OH-D were positively correlated with BMD of each part. Multiple stepwise regression analysis showed that glycosylated hemoglobin, TG, LDL, and TPINP were negatively correlated with BMD, while 25-OH-D was positively correlated with BMD. Conclusion Postmenopausal patients with type 2 diabetes should pay attention to vitamin D supplementation, good control of blood glucose, comprehensive examination of blood lipid and bone metabolism, and early control of risk factors related to osteoporosis. |