| Objective To explore the effects of non-steroidal anti-inflammatory drugs (NSAIDs), tumor necrosis factor inhibitors (TNFi), and disease-relieving anti-rheumatic drugs (DMARDs) on the improvement of condition, bone mineral density, and vertebral fractures in patients with ankylosing spondylitis. Methods Sequential design was adopted to randomly divide the patients into 3 groups, NSAIDs group, TNFi group, and DMARDs group, and 60 patients were enrolled in each group sequentially. The patients in each group received corresponding drugs for one year. The disease improvement, bone mineral density, and vertebrate fractures in patients of the three groups were followed up. Results The completed follow-up patients in NSAIDs, TNFi, and DMARDs were 43, 46, and 47, respectively. Compared with those before the treatment, the levels of C-reactive protein, erythrocyte sedimentation, and P substances decreased in patients of the three groups after the treatment. Bone mineral density of the lumbar and hip increased. The number of vertebral fractures increased. Conclusion NSAIDs, TNFi, DMARDs have better effects on the relieve of morbidity and bone mineral density of patients with ankylosing spondylitis, but they cannot relieve the process of vertebral fractures. |