中国骨质疏松杂志

骨转换标志物CTX-1和PINP预测骨质疏松骨折的研究进展

Research progress of bone turnover markers CTX-1 and PINP in predicting osteoporotic fractures

DOI：10.3969/j.issn.1006-7108.2021.07.028

英文关键词:bone turnover markers osteoporotic fracture risk prediction

基金项目:天津市卫生局科技基金（2013KZ071）；天津市骨科研究所基金（2019TJGYSKY03）

作者	单位
王湛1 王毅1* 冯凯强1 田爱现2 刘忠玉3	1.天津大学天津医院检验科，天津 300211 2.天津大学天津医院骨科研究所，天津 300211 3.天津大学天津医院下肢科，天津 300211

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中文摘要:

骨质疏松性骨折作为老年人群中的常见病，已成为全球性公共卫生问题，但目前对其发生风险的预测方法有限且准确度不足。近期研究发现骨转换标志物可能对预测骨质疏松性骨折发生有应用前景，现综述近年来有关骨转换标志物（CTX-1和PINP）对骨质疏松性骨折风险预测的研究进展，为临床筛查骨质疏松性骨折发生的高风险人群提供新思维。

英文摘要:

As a common disease in the elderly, osteoporotic fracture has become a global public health problem. However, the current approaches for predicting who might suffer osteoporotic fracture are limited and not accurate. Recent studies have found that bone turnover markers may have application prospects in predicting the incidence of osteoporotic fracture. To provide new thinking for clinical screening of high-risk people of fracture, this review summarizes the research progress of bone turnover markers (CTX-1 and PINP) in predicting the risk of osteoporotic fractures in recent years.

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