| Objective To explore the medication rule of traditional Chinese medicine in promoting postoperative rehabilitation of osteoporotic vertebral compression fracture (OVCF) based on data mining. Methods The OVCF database was established by searching CNKI database, Wanfang database, VIP database and CBM database for literatures about treatment of osteoporotic vertebral compression fracture with traditional Chinese medicine after operation in recent 20 years. Data visualization, cluster analysis, association rule analysis and other methods were used to analyze the usage frequency and drug combination rule of traditional Chinese medicine. Results Through strict filtering criteria, 95 literatures on the treatment of diabetes combined with osteoporosis by traditional Chinese medicine were screened out, involving 76 different recipes and 127 herbs. The high frequency herbs were Angelica, Radix rehmanniae, Eucommia ulmoides, Rhizoma Drynariae, Astragalus membranaceus, Dipsacus, Longspur epimedium, Poria cocos, Dioscorea bidentata, Paeonia alba, Cornus officinalis, Ligusticum wallichii. In the "four Qis" classification, warm drugs are the most common. In the classification of "five flavors", sweet, bitter and spicy herbs are the most frequent. According to the classification of meridian tropism, most of the drugs belong to liver meridian, kidney meridian or spleen meridian. According to the efficacy classification, the main drug categories were Yang tonifying drugs, blood activating and stasis removing drugs, Qi tonifying drugs, Yin nourishing drugs and blood enriching drugs. Four clusters were identified by cluster analysis of high frequency Chinese medicines. Association rule analysis obtains 6 and 4 association rules for the compatibility of 2 and 3 drugs. Association network analysis of herbal medicine of high frequency results in 3 strong associations. Conclusion In traditional Chinese medicine treatment of OVCF after operation, deficiency-nourishing drugs blood-activiating and stasis-dissolving drugs are the most frequently used, which are mostly compatibility of tastes of sweet, bitter and spicy and nature of warm. The core of the treatment is "tonifying deficiency and removing blood stasis" in the compatibility of drugs, and the treatment includes nourishing Yin, strengthening yang, tonifying qi and activating blood circulation, removing blood stasis and relieving pain. |