Objective To explore the correlation between oxytocin and bone metabolism and bone mineral density of lumbar vertebrae and hip in postmenopausal women. Methods the concentrations of serum oxytocin, leptin, estrogen and bone metabolic markers were measured in 185 cases of normal bone mineral density and 132 cases of osteoporosis. The BMD of lumbar vertebrae and femoral neck were measured by dual energy X-ray absorptiometry. The relationship between oxytocin level and bone mineral density was explored. Results The serum oxytocin concentration in the osteoporotic women was lower than that in the normal bone mineral density women (P<0.05). In osteoporosis group, serum oxytocin concentration was negatively correlated with age, menopausal years, BMI, serum PINP, BLAP and CTX, and positively correlated with leptin and estrogen. In normal bone mineral density group, no significant correlation was found between serum oxytocin concentration and various indexes. After adjusting age and BMI, the BMD of lumbar vertebrae and femoral neck was still negatively correlated with the years of menopause and the concentrations of serum PINP, BLAP and CTX, and positively correlated with the concentrations of estrogen, leptin and oxytocin. After adjusting for age and BMI, multiple regression analysis showed that years of menopause, serum oxytocin, PINP and CTX were significant predictors of bone mineral density of lumbar vertebrae and femoral neck. Conclusion The level of serum oxytocin in postmenopausal women is related to high bone mineral density of lumbar vertebrae and femoral neck. |