| Objective To study the bone metabolism turnover in maintenance hemodialysis patients through the detection of the bone turnover markers. Methods Seventy-seven uremia patients on maintenance hemodialysis were randomly selected as the study group to observe the status of bone loss by measuring the bone turnover markers. Results According to PTH, the study group was divided into 3 groups: group A (PTH < 150 pg/mL), group B (150 pg/mL≤PTH＜300 pg/mL ), and group C (PTH≥300 pg/mL). There were significant differences in age, creatinine, blood β-microglobulin, glomerular filtration rate, blood phosphorus, calcium-phosphorus product, BGP, N-MID, and β-CTX among the three groups. The levels of β-CTX, N-MID, BGP, calcium-phosphorus product, blood phosphorus, blood β-microglobulin showed an ascending manner from group A to group B to group C. Age and glomerular filtration rate showed an ascending manner from group C to group B to group A. β-CTX was divided into four groups, group A (0.725±0.225 pg/mL), group B (1.264±0.136 pg/mL), group C (1.699±0.184 pg/mL), and group D (3.126±0.849 pg/mL) according to the quartile method. There were significant differences in GFR, calcium-phosphorus product, parathyroid hormone, BGP, and N-MID among the 4 groups. When β-CTX elevated, the product of calcium and phosphorus, PTH, BGP, and N-MID increased, but GFR decreased. Conclusion With the increase of PTH and the decrease of GFR in maintenance hemodialysis patients, the levels of BGP, N-MID, and β-CTX that reflect the status of bone metabolism increase, the bone metabolism is active, and the bone loss is aggravated. |