阿仑膦酸钠联合阿托伐他汀治疗糖尿病合并骨质疏松症的Meta分析
Based on the meta analysis of alendronate combined with atorvastatin in the treatments of diabetes mellitus with osteoporosis
  
DOI:10.3969/j.issn.1006-7108.2021.08.021
中文关键词:  糖尿病  骨质疏松症  阿仑膦酸钠  阿托伐他汀  Meta分析
英文关键词:diabetes mellitus  osteoporosis  alendronate  atorvastatin  Meta analysis
基金项目:
作者单位
敖先伟 张艳芳 毕红兵 任长青 孙晓顺* 荆州市第二人民医院湖北 荆州 434000 
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中文摘要:
      目的 系统评价阿仑膦酸钠片联合阿托伐他汀治疗糖尿病合并骨质疏松症的临床疗效及安全性。方法 检索知网(CNKI)、维普(VIP)、万方(Wanfang)、PubMed、the Cochrane library及Embase数据库中以阿仑膦酸钠片联合阿托伐他汀为基本方案治疗糖尿病合并骨质疏松症的临床随机对照试验(RCTs)。运用Stata14.0软件对纳入文献进行Meta分析。结果 共纳入10篇RCT文献,包括937例研究对象,其中观察组471例,对照组466例。Meta分析结果显示:阿仑膦酸钠片联合阿托伐他汀治疗糖尿病合并骨质疏松症与单用阿仑膦酸钠片比较,在骨密度(bone mineral density, BMD)改变中,腰椎SMD为0.38(0.25,0.51)、股骨颈SMD为0.55(0.42,0.68)、股骨粗隆SMD为0.54(0.41,0.67)、前臂SMD为0.45(0.32,0.58),均有统计学意义。并且阿仑膦酸钠片联合阿托伐他汀治疗能降低疼痛评分,其SMD为-3.07(-3.90,-2.23),各种不良反应比较差异无统计学意义。结论 以阿仑膦酸钠片联合阿托伐他汀为基础方案治疗糖尿病合并骨质疏松症较单用阿仑膦酸钠片能提高临床疗效,降低不良反应。
英文摘要:
      Objective To systematically evaluate the clinical efficacy and safety of alendronate sodium tablets combined with atorvastatin in the treatments of diabetes with osteoporosis . Methods According to search for the CNKI, VIP, Wanfang, PubMed, the Cochrane library and Embase database, and find out the basic plans of alendronate sodium that combined with atorvastatin were used to treat diabetes with bone Randomized Controlled Trials (RCTs) of Clinical Porosity. Then used the Stata14.0 software to analyze the included literatures. Results A total of 10 RCT literatures and 937 subjects were included, there are 471 in the observation group and 466 in the control group. Meta-analysis results showed that: compared with alendronate sodium tablets that combined with atorvastatin calcium in the treatments of diabetes and osteoporosis, the bone mineral density (BMD) changes in the lumbar spine SMD was 0.38 (0.25, 0.51) ), femoral neck SMD was 0.55 (0.42, 0.68), femoral tuberosity SMD was 0.54 (0.41, 0.67), forearm SMD was 0.45 (0.32, 0.58), All of them were significant statistically. It could also reduce the pain score, SMD is -3.07 (-3.90, -2.23), there was no statistical difference in RR of various adverse reactions. Conclusion Compared with alendronate sodium tablets that combined with atorvastatin as the basic regimen in the treatment of diabetes with osteoporosis, it can improve the clinical efficacy and reduce adverse reactions
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