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| 膜1型基质金属蛋白酶在骨代谢作用中的研究进展 |
| Research progress of membrane 1 matrix metalloproteinase in bone metabolism |
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| DOI：10.3969/j.issn.1006-7108.2021.08.023 |
| 中文关键词: 膜1型基质金属蛋白酶 骨代谢 骨形成 骨吸收 |
| 英文关键词:MT1-MMP bone metabolism bone formation bone resorption |
| 基金项目:国家自然科学基金（11602046）；重庆市渝中区基础研究与前沿探索项目（20190114）；重庆医科大学生命科学研究院大学生科学研究与创新实验项目（201901） |
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| 中文摘要: |
| 基质金属蛋白酶是一类锌依赖性内肽酶，可降解大多数细胞外基质。膜1型基质金属蛋白酶（membrane type-1 matrix metalloproteinase，MT1-MMP或MMP14）属于基质金属蛋白酶家族，是唯一一种能够直接促进细胞向3D胶原蛋白基质入侵的胶原酶。骨细胞胞外基质在骨形成和骨吸收过程中发挥重要作用，MT1-MMP通过影响胞外基质引起骨骼相关的病理、生理变化。本文拟就近年MT1-MMP在骨代谢作用中的研究进展进行综述，旨在为MT1-MMP在骨代谢疾病的药理干预、骨生物工程中的应用提供新思路。 |
| 英文摘要: |
| Matrix Metalloproteinases (MMPs) are a type of zinc-dependent endopeptidases, which can degrade most of the extracellular matrix metalloproteinases. Membrane type-1 matrix metalloproteinase (MT1-MMP) is a unique MMP, as the collagenase to promote cell invasion into 3D collagen matrix directly. Extracellular matrix (ECM) plays an important role in the process of bone formation and bone absorption. MT1-MMP can induce the bone-related pathological and physiological changes via ECM. This article intends to review the research progress of MT1-MMP in bone metabolism in recent years, aiming to provide new ideas for pharmacological intervention of MT1-MMP in anti-bone resorption and its application in bone bioengineering. |
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