| Objective To explore the related factors of decreased bone content and osteoporosis in middle-aged and aged men, so as to provide reference for the prevention and development of decreased bone content and osteoporosis. Methods Middle-aged and elderly men who had physical examination in a third-grade hospital from January 1, 2017 to August 31, 2020 were selected as the study subjects. Fasting blood glucose, high-density lipoprotein, and other biochemical indexes were measured. Bone mineral density of the lumbar spine and hip joint was measured with dual-energy X-ray absorptiometry. Results Univariate logistic regression analysis showed that BMI, waist circumference, blood glucose, and high-density lipoprotein had statistical significance (P < 0.05). Underweight and blood glucose were risk factors for disease progression. Moderate obesity and high-density lipoprotein were protective factors for disease progression. Multiple logistic regression showed that BMI and blood glucose were related factors of disease progression, and the difference was statistically significant. Compared to normal BMI, lean body mass was a risk factor for disease progression, while moderate obesity was a protective factor for disease progression. Patients with poor blood glucose control had 1.4 times high risk of disease progression compared to those with normal blood glucose control, and the difference was statistically significant. Conclusion Age, BMI, waist circumference, blood glucose, and high-density lipoprotein are related factors for the progression of bone content reduction to osteoporosis. Among those, BMI and blood glucose may be comprehensive factors for disease progression. It is necessary to consider all kinds of factors when preventing bone content reduction from progressing to osteoporosis. |