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| 脾肾阳虚证狼疮性肾炎继发骨质疏松的临床特征及影响因素 |
| Clinical characteristics and influential factors of osteoporosis secondary to lupus nephritis with spleen kidney yang deficiency syndrome |
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| DOI：10.3969/j.issn.1006-7108.2021.09.009 |
| 中文关键词: 狼疮性肾炎 骨质疏松 脾肾阳虚证 影响因素 |
| 英文关键词:lupus nephritis, osteoporosis, spleen kidney yang deficiency syndrome, influential factors |
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| 中文摘要: |
| 目的 探讨脾肾阳虚证狼疮性肾炎继发骨质疏松的临床特征及相关影响因素。方法 收集本院门诊及病房就诊的脾肾阳虚证狼疮性肾炎的患者。依据骨质疏松诊断标准，将入组患者分为骨质疏松组（OP组）与非骨质疏松组（非OP组）。记录、观察患者一般疾病特征、骨密度值、受累脏器、临床表现、实验室指标、SLEDAI评分，建立数据库。通过数据统计分析、比较，获得两组间的临床特征差异，通过回归分析得出继发骨质疏松的危险因素。结果 本研究共纳入60例脾肾阳虚的狼疮性肾炎患者，OP组、非OP组各30例，OP组平均年龄42.1岁,平均病程113.8个月；非OP组平均年龄34.5岁,平均病程68.2个月。两组比较，OP组的年龄更大、病程更长，肝脏受累较多，畏寒、骨痛、心包积液相对常见，尿蛋白定量明显增多，尿素氮、胱抑素C、血沉、CRP升高更明显，肾小球滤过率、25羟基维生素D更低，差异均有统计学意义。回归分析发现，狼疮性肾炎继发骨质疏松的影响因素包括年龄大、病程长、尿素氮升高。结论 脾肾阳虚证的狼疮性肾炎继发骨质疏松患者年龄更大、病程更长，多伴有肝脏、血液系统受累，临床上还可出现大量蛋白尿、肾功能显著下降。 |
| 英文摘要: |
| Objective To investigate the clinical characteristics and related influential factors of osteoporosis secondary to lupus nephritis with spleen kidney yang deficiency syndrome. Methods Patients with lupus nephritis with spleen kidney yang deficiency syndrome were collected from the inpatient and outpatient department of our hospital. According to the diagnostic criteria of osteoporosis, the patients were divided into osteoporosis group (OP group) and non osteoporosis group (non-OP group). The general disease characteristics, bone mineral density, involved organs, clinical manifestations, laboratory indicators, SLEDAI score were recorded and observed, and the database was established. The differences between the two groups were obtained by statistical analysis of the risk factors of osteoporosis. Results A total of 60 lupus nephritis patients with spleen and kidney yang deficiency were included in this study, with 30 cases in OP group and 30 cases in non-OP group. The average age was 42.1 years old, and the average course of disease was 113.8 months in OP group. The average age was 34.5 years old, and the average course of disease was 68.2 months in non-OP group. Comparing to non-OP groups, OP group had older age, longer course of disease, more liver involvement, chills, and bone pain. Pericardial effusion were relatively common, urinary protein quantitative increased significantly, urea nitrogen, Cystatin C, erythrocyte sedimentation rate, and CRP increased more significantly, and glomerular filtration rate and 25 hydroxyvitamin D were lower in OP group, and the differences were significant. Conclusion Patients with lupus nephritis secondary to osteoporosis with spleen kidney yang deficiency syndrome are older, with longer course of disease, liver and blood system involvement, a large amount of proteinuria, and significant decline of renal function in clinic. |
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