| Objective To study the relationship between polymorphism and mutation in low-density lipoprotein receptor-related protein 5 (LRP5) gene A1330V and Q89R and type 2 diabetes (T2DM) patinets with postmenopausal osteoporosis (OP). Methods A total of 81 postmenopausal T2DM patients in the outpatient department of our hospital were selected. According to whether they were associated with OP, they were divided into T2DM with OP group, with 39 cases, T2DM group, with 42 cases, and OP alone group, with 40 cases. Forty postmenopausal healthy women in the physical examination center during the same period were as the control group. Gene sequencing technology was used to detect the polymorphism of LRP5 gene A1330V and Q89R. Results HbAIC and FINS in the T2DM with OP group were higher than those in the control group, while the waist L2-4 BMD and femoral neck BMD were lower than those of the control group. HbAIC and FINS in the T2DM group were higher than those in the control group, and the difference was statistically significant (P<0.05). The AA type, AV type, and VV type composition at A1330V site of LRP5 gene in T2DM with OP group, T2DM group, and OP group were statistically significant compared to those in the control group (P <0.05). There was no significant difference in the genotype distribution at the Q89R locus of LRP5 gene between each group (P>0.05). The differences of AA type, AV type, and VV type at A1330V locus of LRP5 gene, HbAIC, waist L2-4 BMD, and femoral neck BMD in T2DM with OP group were statistically significant (P <0.05). There was no significant difference among AA, AV, VV, TRACP-5b, BALP, and FINS (P>0.05). Conclusion LRP5 gene may be a susceptibility gene for T2DM and OP in postmenopausal women. Polymorphism and mutation at the A1330V locus may affect the occurrence of T2DM and OP in postmenopausal women. |