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| 绝经后女性血清硒水平与骨质疏松骨密度和骨代谢指标相关性研究 |
| Relationship between serum selenium level and bone mineral density and bone metabolism indexes in postmenopausal women |
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| DOI：10.3969/j.issn.1006-7108.2021.09.016 |
| 中文关键词: 绝经后骨质疏松症 硒 年龄 骨密度 |
| 英文关键词:postmenopausal osteoporosis, selenium, age, bone mineral density |
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| 中文摘要: |
| 目的 探索血清硒水平与绝经后妇女骨代谢指标以及腰椎和髋部骨密度之间相关性。方法 检测156例正常骨密度和162例骨质疏松症的血清硒、25-羟基维生素D、PTH、骨钙素、PINP、CTX和NTX/Cr等指标水平。腰椎和股骨颈的BMD通过双能X线吸收法测量。探索了血清硒水平与骨密度的关系。结果 骨质疏松症女性的血清硒水平低于正常骨密度的女性(P＜0.05)。在骨质疏松症妇女中，血清硒水平与年龄、绝经年限、BMI、PTH、骨钙素、PINP、CTX和NTX/Cr水平呈负相关，与25-羟基维生素D水平呈正相关。在正常骨密度组，血清硒水平与这些参数均未发现明显的相关性。调整年龄和BMI后，腰椎和股骨颈骨密度与血清硒及25-羟基维生素D水平呈显著正相关，与绝经年限、PTH、骨钙素、PINP、CTX和NTX/Cr呈负相关。对年龄和BMI进行调整后，进行多元回归分析以确定BMD的预测因子，血清硒和PINP、CTX是腰椎和股骨颈骨密度的显著预测因子。结论 绝经后女性患者血清硒水平降低与腰椎和股骨颈骨密度降低密切有关。 |
| 英文摘要: |
| Objective To explore the correlation between serum selenium level and bone metabolism index and bone mineral density (BMD) of the lumbar vertebrae and hip in postmenopausal women. Methods Serum levels of selenium, 25-hydroxyvitamin D, PTH, osteocalcin, PINP, CTX, and NTX/Cr were measured in 156 cases with normal BMD and 162 cases with osteoporosis. BMD of the lumbar vertebrae and femoral neck was measured with dual energy X-ray absorptiometry. The relationship between serum selenium level and BMD was explored. Results Serum levels of selenium in women with osteoporosis was lower than those in women with normal BMD (P < 0.05). In women with osteoporosis, the levels of serum selenium were negatively correlated with age, menopausal years, BMI, PTH, osteocalcin, PINP, CTX, and NTX/Cr, but were positively correlated with the concentration of 25-hydroxyvitamin D. No significant correlation was found between serum selenium concentration and above parameters in normal BMD group. After adjusting age and BMI, BMD of the lumbar vertebrae and femoral neck was positively correlated with serum selenium and 25-hydroxyvitamin D concentration, but was negatively correlated with menopausal years, PTH, osteocalcin, PINP, CTX, and NTX/Cr. After adjusting for age and BMI, multiple regression analysis was performed to determine the predictors of BMD. Serum selenium, PINP, and CTX were significant predictors of BMD of the lumbar vertebrae and femoral neck. Conclusion The decrease of serum selenium level in postmenopausal women is closely correlated to the decrease of BMD of the lumbar vertebrae and femoral neck. |
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