| Objective To evaluate the the diagnostic value of IOF one-minute risk test combined with quantitative ultrasound screening for the diagnosis of osteoporosis. Methods Four hundred postmenopausal women and men older than 50 years old were selected as the research subjects. A questionnaire was designed. Data of population, disease history, and osteoporosis-related risk factors of the subjects were collected. IOF one-minute osteoporosis risk test (IOF), quantitative ultrasound (QUS-T), and dual-energy X-ray absorptiometry (DEX) were examined. Results When IOF and QUS-T were used as the screening criteria alone, the area under the ROC curve was 0.676 and 0.832, and the cut-off point was 6.5 and ?2.75, and the Yoden indexes were 0.278 and 0.527, respectively. When IOF combined with QUS-T was used as the screening standard, the area under the ROC curve was 0.834, with Y=23.196, and the sensitivity and specificity were 64.8％and 91.1%, respectively. When osteoporosis was diagnosed either with IOF ≥ 6.5 or with QUS-T ≤ ?2.75, the sensitivity was 77.84%, the specificity was 62.05%, and the Yoden index was 0.5463. When osteoporosis was diagnosed together with IOF ≥ 6.5 and QUS-T ≤ ?2.75, the sensitivity was 29.55%, the specificity was 96.43%, and the Yoden index was 0.2598. Conclusion The use of IOF and QUS-T alone or in combination to screen for osteoporosis has a certain diagnostic value, but it still needs further verification. |