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| 基于中医传承辅助平台研究黄宏兴教授治疗原发性骨质疏松症的用药规律 |
| Analysis on the medication rule of the treatment of primary osteoporosis by professor Hongxing Huang based on traditional Chinese medicine inheritance support system |
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| DOI：10.3969/j.issn.1006-7108.2021.09.020 |
| 中文关键词: 中医传承辅助平台 原发性骨质疏松症 思想传承 用药规律 |
| 英文关键词:traditional Chinese medicine inheritance support system, primary osteoporosis, ideological inheritance, medication rule |
| 基金项目:国家自然科学基金(81673786，81674004，81973886)；广州中医药大学学科研究重点项目(XK2019028) |
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| 中文摘要: |
| 目的 基于中医传承辅助平台软件( V2.5)，分析黄宏兴教授治疗原发性骨质疏松症(primary osteoporosis, POP)的中医处方用药规律，探讨与继承黄宏兴教授治疗POP的辨治思想与用药经验。方法 收集2017年5月至2020年11月广州中医药大学第三附属医院黄宏兴教授门诊的POP病历，建立处方用药数据库，分别进行纳入中药频次统计、药性统计、关联规则分析、熵聚类分析。结果 共纳入方剂50首，涉及药物54 味，分析得到高频用药包括甘草、半枫荷、黄芪、救必应、丹参、续断、杜仲等16味，纳入的中药多属温性药，多具甘、苦或辛味，归于肝经、肾经、脾经居多。另获取常用药物组合20组，挖掘新方8首。结论 黄宏兴教授运用中医中药治疗POP，依据理论为，肾主骨理论、脾肾相关论、肝肾同源论与血瘀论，把握骨痿的病因病机，结合岭南中医药的特色，以补肾、健脾、活血为治则处方选药。 |
| 英文摘要: |
| Objective To analyze professor Huang Hongxing's prescription medication rule in the treatment of primary osteoporosis (POP) based on traditional Chinese medicine inheritance support system (V2.5), and to discuss the ideology of syndrome differentiation and medication experience of POP. Methods The medical records of POP cases in Professor Huang Hongxing's outpatient department of the Third Affiliated Hospital of Guangzhou University of Chinese Medicine from May 2017 to November 2020 were collected. The prescription medication database was established. The frequency of included traditional Chinese medicine statistics, drug property statistics, association rule analysis, and entropy cluster analysis were carried out, respectively. Results A total of 50 prescriptions were included, involving 54 drugs. Sixteen high-frequency drugs including licorice, banfenghe, astragalus membranaceus, jiubiying, the root of red-rooted salvia, radix dipsaci, and tu-chung were obtained. Most of the included Chinese medicines were warm drugs with sweet, bitter or pungent taste, and most of them belong to liver meridian, kidney meridian, and spleen meridian. Twenty groups of commonly used drug combinations were obtained, and 8 new prescriptions were excavated. Conclusion Professor Hongxing Huang uses traditional Chinese medicine to treat POP according to kidney governing bone theory, spleen-kidney correlation theory, liver and kidney homology theory, and blood stasis theory. Professor Hongxing Huang grasps the etiology and pathogenesis of bone flaccidity combined with the characteristics of Lingnan traditional Chinese medicine, and takes tonifying the kidney, strengthening the spleen, and promoting blood circulation as the treatment principles. |
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