| Rheumatoid arthritis (RA) is a systemic autoimmune disease involving multiple joints, often involving facet joints, and the lesions are symmetrical, invasive, and disabled. At the later stage of rheumatoid arthritis, it is easy to cause irreversible destruction of the cartilage, bone, and other adjacent tissues, resulting in serious joint deformities and even disabilities, causing serious physical and psychological damage to patients and their families, and seriously affecting the quality of life. So far, although there are many drugs to treat RA, RA still can not be completely cured. The reason is that the pathogenesis of RA and its bone destruction is still not completely clear. Therefore, it is very important to understand the pathogenesis and to treat the bone destruction of RA. Generally speaking, the pathogenesis of RA bone destruction is caused by the imbalance between osteoblasts and osteoclasts. This paper reviews and discusses the relevant research literature involved in articular cartilage destruction and bone erosion of RA in recent years, and explores the pathogenesis of RA bone destruction caused by the influence between osteoblasts and osteoclasts from three different aspects: cytokines/chemokines, non-coding RNA, and signal pathway. The purpose of this study is to provide a new idea for the study of the pathogenesis of bone destruction in RA. Traditional Chinese medicine plays an important role in the prevention of RA bone destruction, and it can ensure its safety on the premise of ensuring the curative effect. Therefore, in-depth research on the pathogenesis of bone destruction of RA and the role of traditional Chinese medicine in its treatment can provide new research ideas for its treatment. |