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| 妊娠合并甲亢母亲所娩新生儿骨密度不足的影响因素分析 |
| Analysis of influential factors of insufficiency of bone mineral density in newborns by women with hyperthyroidism |
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| DOI：10.3969/j.issn.1006-7108.2021.10.011 |
| 中文关键词: 妊娠期 甲亢 新生儿 骨密度 影响因素 |
| 英文关键词:pregnancy hyperthyroidism newborn bone mineral density influential factors |
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| 中文摘要: |
| 目的 探讨妊娠合并甲亢母亲所娩新生儿骨密度不足的影响因素。方法 选取180名妊娠合并甲亢母亲（甲亢组）和180名妊娠期正常母亲（对照组）。分析两组母亲所产新生儿的骨密度情况。收集甲亢组临床资料，分析妊娠合并甲亢母亲所娩新生儿骨密度的影响因素。结果 甲亢组所产新生儿骨密度不足发生率为27.22 %（49/180）显著高于对照组的7.78 %（14/180），差异有统计学意义（P﹤0.05）。Logistic回归分析得出：孕期日均户外活动﹤1 h、未规律补钙、未规律补充维生素D、血清钙≤2.45 mmol/L、骨钙素（OC）﹤6.20 μg/L和碱性磷酸酶（ALP）< 171.47 μ/L是妊娠合并甲亢母亲所娩新生儿骨密度不足的影响因素（P﹤0.05）。结论 妊娠合并甲亢母亲所娩新生儿骨密度不足与孕期户外活动少、孕期未规律补钙和维生素D以及血清钙、OC、ALP水平低下有关。提倡孕妇适当户外活动，规律补钙和维生素D。 |
| 英文摘要: |
| Objective To explore the influential factors of insufficiency of bone mineral density in newborns delivered by pregnant mothers with hyperthyroidism. Methods One hundred and eighty pregnant mothers with hyperthyroidism (hyperthyroidism group) and 180 normal pregnant mothers (control group) were selected. Bone mineral density of the newborns by mothers in the two groups was analyzed. Clinical data of the hyperthyroidism group were collected. The influential factors of bone mineral density of newborns delivered by pregnant mothers with hyperthyroidism were analyzed. Results The incidence of low bone mineral density among newborns in the hyperthyroidism group (27.22%, 49/180) was higher than that in the control group (7.78%, 14/180). The difference was statistically significant (P<0.05). The results of logistic regression analysis showed that the average daily outdoor activities during pregnancy <1 h, irregular calcium supplementation, irregular vitamin D supplementation, serum calcium ≤2.45 mmol/L, osteocalcin (OC) <6.20 μg/L, and alkaline phosphatase (ALP) <171.47 μ /L were influential factors of bone mineral density of newborns delivered by pregnant mothers with hyperthyroidism (P<0.05). Conclusion Insufficient bone mineral density of newborns by pregnant mothers with hyperthyroidism is related to less outdoor activities during pregnancy, irregular calcium and vitamin D supplementation during pregnancy, and low levels of serum calcium, OC, and ALP. Appropriate outdoor activities for pregnant women and regular calcium and vitamin D supplementation should be advocated. |
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