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| Wnt/β-catenin信号通路调控成骨细胞、破骨细胞在骨质疏松中的作用探讨 |
| Role of Wnt/β-catenin signaling in the regulation of osteoblasts and osteoclasts in osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2021.10.026 |
| 中文关键词: Wnt /β-catenin信号 骨质疏松 成骨细胞 破骨细胞 |
| 英文关键词:Wnt/β-catenin signaling osteoporosis osteoblast osteoclast |
| 基金项目:国际课题《IOF对骨量减少人群骨折风险评估( FRAX)前瞻性研究》(IOFCJO-D001);广西重点研发项目《OLFM4在老年性骨质疏松发生中的作用和机制研究》(2018AB58086) |
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| 中文摘要: |
| 骨质疏松症是一种导致骨骼疏松、强度降低、易发生骨骼疼痛和脆性骨折的常见慢性病，影响了全球大部分中老年人健康。目前应用钙剂、维生素D补充剂、双膦酸盐类和雌激素等药物治疗，其主要侧重于预防、延缓骨吸收。针对骨质疏松症需要精准于细胞动力学和分化的靶向治疗药物。通过不断的探索和研究骨质疏松中涉及的信号通路，发现Wnt/β-catenin在骨正常生长和代谢中极为重要，β-catenin是介导成骨细胞存活和分化的关键分子。罗莫珠单抗、狄诺塞麦等新研发药物通过调节Wnt/β-catenin信号通路，进而影响骨髓间充质干细胞的成骨作用、成骨细胞的增殖和分化以及破骨细胞的生成等，参与骨质疏松的调节。本文就β-catenin在成骨细胞、破骨细胞功能调控和骨质疏松中的具体作用进行总结，进一步探讨Wnt蛋白和β-catenin的研究进展，以发掘更多创新的靶点来解决骨质疏松症的治疗问题。 |
| 英文摘要: |
| Osteoporosis is a common chronic disease leading to osteopenia, reduced strength, bone pain and fragile fractures. It affects the health of most middle-aged and elderly people worldwide. Calcium, vitamin D supplements, bisphosphonates, estrogens and other medications are used to focus on preventing and delaying bone resorption. Osteoporosis requires targeted therapeutics that are precise in cell dynamics and differentiation. Through continuous exploration and study of the signaling pathways involved in osteoporosis, we found that Wnt/β-catenin is extremely important in normal bone growth and metabolism. β-catenin is a key molecule mediating the survival and differentiation of osteoblasts. New drugs such as Romozumab and Denosumab are involved in the regulation of osteoporosis by regulating the activity of Wnt/β-catenin signaling pathway, which affects the osteogenesis of BMSC, the proliferation and differentiation of osteoblasts and the generation of osteoclasts. This article summarizes the specific role of β-catenin in the regulation of osteoblasts, osteoclasts and osteoporosis. We explore the research progress of Wnt proteins and β-catenin in order to discover more innovative targets for the treatment of osteoporosis. |
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