| The incidence of osteoporosis is getting higher and higher, but the pathogenesis is still complex, related research has been a hot topic in this field. At present, proteomics is gradually being applied to the research field of the pathogenesis of osteoporosis. Its advantage is that protein is the direct executor of cell function, through high-throughput and highly automated technology, it can screen the molecules that directly affect the occurrence and development of the disease, which is helpful to clarify the pathogenesis of osteoporosis. In addition, the results of proteomic analysis can not only provide an important reference for the establishment of disease-related biomarkers, but also provide an important experimental basis for the development of some new osteoporosis diagnosis or osteoporotic fracture prediction methods. This paper reviews the proteomic studies related to osteoporosis in recent years, classified according to different species and tissue sources, and reviews the progress of human proteomics (including monocytes, serum plasma, exocrine and bone tissue) and animal proteomics in the field of osteoporosis. In addition, according to the proteomic results of different races, genders and ages, this paper specifically analyzes the biological functions of some important differential proteins in the process of human bone metabolism or cell differentiation in vitro. The aim is to provide new inspiration for medical staff and researchers in the field of osteoporosis, and to provide valuable reference for follow-up clinical transformation research. |