| Objective To observe the effect of vitamin D (VitD) on serum levels of osteoprotectin (OPG) and chemerin in patients with type 2 diabetes mellitus (T2DM) complicated with osteoporosis (OP), and to explore the preliminary.roles in the progression of disease Methods A total of 123 patients with T2DM complicated with OP who were admitted to our hospital from July 2020 to December 2020 were selected and divided into 3 groups according to the levels of serum 25(OH)D, which were VitD normal group (40 cases), VitD insufficient group (42 cases), and VitD deficiency group (41 cases). During the same period, 40 healthy persons from the physical examination center of our hospital were selected as the control group (NC group). VitD insufficient group and VitD deficiency group were given VitD2 15mg by intramuscular injection, once every 4 weeks for 12 consecutive weeks. The general data of patients were collected. The serum levels of TC, TG, HDL-C, LDL-C, 25(OH)D, FPG, FINS, HbA1c, OPG, and chemerin were detected before and after treatment. Bone mineral density (BMD) of the femoral neck was measured with dual-energy X-ray absorptiometry before and after treatment. The correlation between various factors and femoral neck BMD was analyzed. Results After 12 weeks of treatment, serum TG, HbA1c, OPG, and chemerin in the VitD-insufficient group and the VitD-deficient group decreased significantly compared to those before treatment, while HDL-C, 25(OH)D, and femoral neck BMD increased significantly compared to those before treatment (P<0.05). In VitD- insufficient group, serum levels of HbA1c, 25(OH)D, and femoral neck BMD at 4 weeks did not changed significantly (P>0.05), TG, OPG, and chemerin decreased significantly (P<0.05), and HDL-C increased significantly compared to those before treatment (P<0.05). In the VitD-deficient group, the serum levels of HDL-C, 25(OH)D, and femoral neck BMD increased significantly after 4 weeks of treatment (P<0.05), and the serum levels of TG, OPG, and chemerin decreased significantly compared to those before treatment (P<0.05). Femoral neck BMD was significantly positively correlated with serum 25(OH)D and HDL-C, and negatively correlated with OPG, chemerin, and HbA1c. Serum TG, LDL-C, HbA1c, 25(OH)D, OPG, and chemerin were influencing factors of femoral neck BMD. Conclusion VitD may affect BMD of patients with T2DM complicated with OP by increasing the level of serum VitD and decreasing OPG and chemerin. |