| Objective To analysis the differentially expressed miRNAs and the relationship between osteoporosis and Alzheimer's disease based on bioinformatics. Methods The gene chips of osteoporosis (OP) and Alzheimer's disease (AD) were obtained using Gene Expression Omnibus (GEO) database. The differentially expressed microRNAs (DEmiRNAs) between OP and AD were obtained using GEO2R online analysis. Target genes for the selected DEmiRNAs were predicted using miRDB database and Targetscan database; The DAVID database was used to analyze the target genes with GO analysis and KEGG signal pathway analysis. A protein interaction network and a DEmiRNAs-mRNA regulatory network were created with the STRING database. Results There were 9 meaningful DEmiRNAs in the gene chips of OP and AD. The top 10 core genes, COL1A1, VEGFA, COL4A1, COL3A1, COL5A1, COL2A1, LOX, COL7A1, IGF1, and COL5A2, were screened through the protein interaction network. At the same time, it was found that hsa-miR-29b-3p and collagen were most closely related to OP and AD. Conclusion By studying the DEmiRNAs and core genes of the two diseases, it is helpful to understand the relationship between OP and AD, to understand the common pathogenesis of the two diseases, and to provide new ideas and directions for the treatment of the two diseases. |